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Description

🧪 Product Profile: GHK-Cu

Product Name: GHK-Cu (Copper Tripeptide-1, Glycyl-L-Histidyl-L-Lysine Copper Complex)
CAS Number: 89030-95-5
Molecular Formula: C₁₄H₂₁CuN₆O₄
Molecular Weight: 400.91 g/mol
Amino Acid Sequence: Glycyl-L-Histidyl-L-Lysine (GHK) chelated with copper(II) ion [Cu²⁺]
Purity: ≥98% (HPLC verified)
Formulation: Lyophilized blue to purple powder (standard vials: 1mg, 5mg, 10mg; bulk quantities available)

🔬 Key Characteristics

GHK-Cu is a naturally occurring copper-peptide complex first isolated from human plasma in 1973 by Dr. Loren Pickart. Its structure consists of the tripeptide Gly-His-Lys (GHK) with high affinity for copper(II) ions, forming a stable chelate that enhances cellular recognition and absorption. The blue-purple coloration arises from the copper(II) coordination complex, while its small molecular weight (~400 Da) ensures excellent skin permeability, allowing deep penetration into the dermis to activate repair mechanisms.

⚙️ Mechanism of Action

• Collagen & Extracellular Matrix Synthesis: Stimulates fibroblasts to produce collagen (types I, III, IV), elastin, and glycosaminoglycans (e.g., hyaluronic acid), enhancing skin elasticity and reducing wrinkle depth.
• Antioxidant & Anti-Inflammatory Activity: Acts as a superoxide dismutase (SOD) mimic, scavenging reactive oxygen species (ROS) and inhibiting metal ion-induced lipid peroxidation. Downregulates pro-inflammatory cytokines (TNF-α, IL-6) to mitigate inflammation-related skin damage.
• Cellular Regeneration: Promotes keratinocyte and fibroblast migration/proliferation, accelerating wound healing in burns, surgical incisions, and post-procedural skin recovery.
• Gene Regulation: Upregulates over 300 genes associated with tissue repair, angiogenesis, and antioxidant defense, while suppressing genes linked to inflammation and carcinogenesis.
• Hair Growth Stimulation: Activates hair follicle stem cells and improves dermal papilla vascularization, promoting anagen phase transition in hair follicles.

📊 Research Applications

• Dermatology: Studies on photoaging reversal, scar remodeling, and post-inflammatory hyperpigmentation.
• Wound Healing: Preclinical models of ischemic ulcers, radiation-induced skin damage, and diabetic wound repair.
• Cosmetic Science: Efficacy evaluation in anti-aging formulations (serums, creams, dermal fillers) for collagen synthesis and wrinkle reduction.
• Regenerative Medicine: Investigation of tissue engineering scaffolds functionalized with GHK-Cu for skin and cartilage regeneration.
• Trichology: Research on androgenetic alopecia and hair follicle miniaturization reversal.

💡 Product Features

• Stability: Lyophilized form stable for 24 months at 2-8°C under dry,避光 conditions; reconstituted solutions (pH 5.5-7.0) stable for 7-14 days refrigerated.
• Bioactivity: Induces collagen synthesis at nanomolar concentrations (EC₅₀ ~10 nM) with minimal cytotoxicity.
• Synergistic Compatibility: Enhances efficacy when combined with hyaluronic acid, vitamin C, or growth factors (e.g., EGF, FGF) in cosmeceutical formulations.
• Colorimetric Properties: Blue-purple hue serves as a natural indicator of copper complex stability; discoloration indicates copper ion dissociation.

⚠️ Disclaimer

For Research Use Only: Not approved for human clinical applications. Avoid mixing with strong acids/chelators (e.g., EDTA) that may disrupt copper coordination. Handle with standard peptide safety protocols, including proper reconstitution in sterile aqueous buffers.

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